In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345. Use indinavir as directed by your doctor. Check the label on the medicine for exact dosing instructions. Pranlukast: CYP3A4 Inhibitors Strong may increase the serum concentration of Pranlukast. Crystalluria and nephrolithiasis may occur during treatment with indinavir. The cumulative frequency of nephrolithiasis is substantially higher in pediatric patients 29% than in adult patients 12. cheap ventolin otc
Eplerenone: CYP3A4 Inhibitors Strong may increase the serum concentration of Eplerenone. Rhame FS, Rawlins SL, Petruschke RA, et al. "Pharmacokinetics of indinavir and ritonavir administered at 667 and 100 milligrams, respectively, every 12 hours compared with indinavir administered at 800 milligrams every 8 hours in human immunodeficiency virus-infected patients. Tell your doctor or dentist that you take indinavir before you receive any medical or dental care, emergency care, or surgery.
The atorvastatin and rosuvastatin doses should be carefully titrated; use the lowest dose necessary with careful monitoring during treatment with Crixivan. Fluticasone use is not recommended in situations where Crixivan is coadministered with a potent CYP3A4 inhibitor such as ritonavir unless the potential benefit to the patient outweighs the risk of systemic corticosteroid side effects. Plasma concentrations may be increased by CRIXIVAN. This information should not be used to decide whether or not to take indinavir or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about indinavir. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to indinavir. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using indinavir.
CYP1A2, CYP2C9, CYP2E1 and CYP2B6. Retapamulin: CYP3A4 Inhibitors Strong may increase the serum concentration of Retapamulin. Management: Avoid this combination in patients less than 2 years old. No action is required in other populations. The risk increases if you are also taking other drugs that increase serotonin, so tell your doctor or pharmacist of all the drugs you take see section. Brexpiprazole: CYP3A4 Inhibitors Strong may increase the serum concentration of Brexpiprazole. Management: Reduce brexpiprazole dose to 50% of usual with a strong CYP3A4 inhibitor; reduce to 25% of usual if used with both a moderate CYP3A4 inhibitor and a CYP2D6 inhibitor, or if a strong CYP3A4 inhibitor is used in a CYP2D6 poor metabolizer.
Lee D, Benson CA, Lewis CE, Grunfeld C, Scherzer R "Prevalence and factors associated with dry skin in HIV infection: the FRAM study. Significance was not tested. Levitra, Staxyn or by international labeling. See full drug interaction monograph for details. Take Crixivan capsules every day as prescribed by your doctor. Continue taking Crixivan unless your doctor tells you to stop. Take the exact amount of Crixivan that your doctor tells you to take, right from the very start. To help make sure you will benefit from Crixivan, you must not skip doses or take "drug holidays". If you don't take Crixivan as prescribed, the activity of Crixivan may be reduced due to resistance. Buprenorphine: CYP3A4 Inhibitors Strong may increase the serum concentration of Buprenorphine. Diabetes: Changes in glucose tolerance, hyperglycemia, exacerbation of diabetes, DKA, and new-onset diabetes mellitus have been reported in patients receiving protease inhibitors. Carcinogenicity studies were conducted in mice and rats. Older adults may be more sensitive to the side effects of this drug, especially drowsiness, dizziness, and QT prolongation see above. Fletcher cv, Brundage RC, Remmel RP et al. Pharmacologic characteristics of indinavir, didanosine, and stavudine in human immunodeficiency virus-infected children receiving combination therapy. Antimicrob Agents Chemother. Alosetron does not improve the symptoms of IBS for everyone. When alosetron does work well, it helps reduce stomach pain and discomfort, bowel urgency, and diarrhea. Some or all symptoms may improve within one to two weeks of treatment. The relationship of this event to ONGLYZA is not known. CRIXIVAN will exacerbate the hyperbilirubinemia seen in neonates. Other medications can affect the removal of from your body, which may affect how trazodone works.
Stop taking alosetron if your IBS symptoms do not improve after 4 weeks of treatment. If you stop taking alosetron, do not start taking it again without your doctor's advice. Significant accumulation was not observed after multiple dosing at 800 mg every 8 hours. As your gets stronger, it can begin to fight off infections you already had, possibly causing disease symptoms to come back. You could also have symptoms if your immune system becomes overactive. This reaction may happen at any time soon after starting or many months later. Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Who should not take Crixivan? Pacanowski J, Poirier JM, Petit I, Meynard JL, Girard PM "Atazanavir urinary stones in an HIV-infected patient. Refer to the quetiapine prescribing information for recommendations on adverse reaction monitoring. F. Do not freeze. The trademarks depicted herein are owned by their respective companies. Ginarte M, Losada E, Prieto A, Lorenzo-Zuniga V, Toribio J "Generalized hair loss induced by indinavir plus ritonavir therapy. Indinavir does not stop the spread of HIV to others through blood or sexual contact. Use barrier methods of birth control eg, condoms if you have HIV infection. Do not share needles, injection supplies, or items like toothbrushes or razors. Comparison to historical data on 16 subjects receiving indinavir alone. Meyers MW. Dear investigator letter regarding VIRAMUNE in combination with protease inhibitors. tolterodine
Aprepitant: CYP3A4 Inhibitors Strong may increase the serum concentration of Aprepitant. Pujol RM, Domingo P, XavierMatiasGuiu, Francia E, Sanbeat MA, Alomar A, Vazquez G "HIV-1 protease inhibitor-associated partial lipodystrophy: Clinicopathologic review of 14 cases. FentaNYL: CYP3A4 Inhibitors Strong may increase the serum concentration of FentaNYL. Management: Monitor patients closely for several days following initiation of this combination, and adjust fentanyl dose as necessary. Indinavir is metabolized by CYP3A4. CRIXIVAN must be taken at intervals of 8 hours. Erlotinib: CYP3A4 Inhibitors Strong may increase the serum concentration of Erlotinib. Management: Avoid use of this combination when possible. When the combination must be used, monitor the patient closely for the development of severe adverse reactions, and if such severe reactions occur, reduce the erlotinib dose in 50 mg decrements. ZERIT without talking to your healthcare provider. Panobinostat: CYP3A4 Inhibitors Strong may increase the serum concentration of Panobinostat. Management: Reduce the panobinostat dose to 10 mg when it must be used with a strong CYP3A4 inhibitor. Lovastatin: CYP3A4 Inhibitors Strong may increase the serum concentration of Lovastatin. Goujard C, Legrand M, Panhard X, et al. "High Variability of Indinavir and Nelfinavir Pharmacokinetics in HIV-Infected Patients with a Sustained Virological Response on Highly Active Antiretroviral Therapy. Gentle DL, Stoller ML, Jarrett TW, Ward JF, Geib KS, Wood AF "Protease inhibitor-induced urolithiasis. RomiDEPsin: CYP3A4 Inhibitors Strong may increase the serum concentration of RomiDEPsin. Meperidine. Protease Inhibitors may decrease the serum concentration of Meperidine. Concentrations of the toxic Normeperidine metabolite may be increased. Nefazodone: Protease Inhibitors may increase the serum concentration of Nefazodone. Management: Consider alternatives to, or reduced doses of, nefazodone in patients treated with HIV protease inhibitors. Monitor patients receiving these combinations closely for toxic effects of nefazodone. Dronedarone: CYP3A4 Inhibitors Strong may increase the serum concentration of Dronedarone. klov.info isoxsuprine
Ask your health care provider any questions you may have about how to use indinavir. The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables. Janssen. Prezista darunavir prescribing information. Titusville, NJ; 2012 Feb. Norvir ritonavir US prescribing information. Abbott Laboratories November, 2015. Tell your doctor right away if you develop symptoms of high such as increased thirst and urination. Ixabepilone: CYP3A4 Inhibitors Strong may increase the serum concentration of Ixabepilone. Advisory Council OARAC. NIH. National Institutes of Health "Guidelines for the use of antiretroviral agents in HIV-1-infected adults and adolescents. Panel on Antiretroviral Guidelines for Adults and Adolescents, US Department of Health and Human Services HHS. Guidelines for the use of antiretroviral agents in HIV-1-infected adults and adolescents May 1, 2014. Updates may be available at HHS AIDS Information AIDSinfo website. Middleton B, Bates DW. High-priority drug-drug interactions for use in electronic health records. Psychiatric: oral paresthesia; depression. Do not split or cut ONGLYZA tablets. Hammer SM, Squires KE, Hughes MD et al for the AIDS Clinical Trials Group 320 Study Team. A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less. N Engl J Med. Since this drug can be absorbed through the and and may harm an unborn baby, women who are pregnant or who may become pregnant should not handle this medication or breathe the dust from the tablets. Varying degrees of HIV-1 cross-resistance have been observed between indinavir and other HIV-1 protease inhibitors. In studies with ritonavir, saquinavir, and amprenavir, the extent and spectrum of cross-resistance varied with the specific mutational patterns observed. In general, the degree of cross-resistance increased with the accumulation of resistance-associated amino acid substitutions. Taking indinavir will not prevent you from passing HIV to other people. Do not have unprotected sex or share razors or toothbrushes. Talk with your doctor about safe ways to prevent HIV transmission during sex. Sharing drug or medicine needles is never safe, even for a healthy person. buy generic benicar store europe
It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs including any herbal medicines or supplements or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you. St. John's wort may decrease the amount of the HIV medicine in your body. The HIV medicine may not work against your HIV infection. According to the manufacturer, indinavir was identified as a component of the kidney stones from 8 of 12 patients in whom nephrolithiasis developed. It is not known whether an additional risk is incurred with the concomitant use of crystalluria-inducing medications such as sulfonamides. Tremblay C, Merrill DP, Chou TC et al. Interactions among combinations of two and three protease inhibitors against drug-susceptible and drug-resistant HIV-1 isolates. J Acquir Immune Defic Syndr. The amount of atorvastatin in your blood may increase and cause harmful effects. Gerberding J. Is antiretroviral treatment after percutaneous HIV exposure justified? Vivus. Stendra avanafil tablets prescribing information. Mountain View, CA; 2012 Apr. Included as part of the PRECAUTIONS section. The recommended dosage of Crixivan is 800 mg usually two 400-mg capsules orally every 8 hours. SMX 3 times daily for 21 days. Indinavir interacts with many other medicines. The risk of indinavir's side effects may be increased or indinavir's effectiveness may be decreased. The risk of the other medicines' side effects may also be increased. This may include severe, life-threatening, or fatal side effects. Check with your doctor and pharmacist to make sure that it is safe for you to take indinavir with all of your other medicines prescription or OTC, natural products, vitamins. Indinavir will not cure or prevent HIV infection or AIDS. It helps keep HIV from reproducing and appears to slow down the destruction of the immune system. This may help delay problems that are usually related to AIDS or HIV disease from occurring. Indinavir will not keep you from spreading HIV to other people. People who receive this medicine may continue to have other problems usually related to AIDS or HIV disease. Talk to your doctor about any medications you are taking. Add 202 mL of purified water to the container.
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Concurrent administration of salmeterol with CRIXIVAN is not recommended. The combination may result in increased risk of cardiovascular adverse events associated with salmeterol, including QT prolongation, palpitations and sinus tachycardia. Daudon M, Estépa, Virard JP et al. Urinary stones in HIV-1-positive patients treated with indinavir. Lancet. Appropriate studies have not been performed on the relationship of age to the effects of indinavir in the pediatric population. Safety and efficacy have not been established. Etoposide Phosphate: Atovaquone may increase the serum concentration of Etoposide Phosphate. Management: Consider separating the administration of atovaquone and etoposide by at least 1 to 2 days. No evidence of mutagenicity or genotoxicity was observed in in vitro microbial mutagenesis Ames tests, in vitro alkaline elution assays for DNA breakage, in vitro and in vivo chromosomal aberration studies, and in vitro mammalian cell mutagenesis assays. No treatment-related effects on mating, fertility, or embryo survival were seen in female rats and no treatment-related effects on mating performance were seen in male rats at doses providing systemic exposure comparable to or slightly higher than that with the clinical dose. In addition, no treatment-related effects were observed in fecundity or fertility of untreated females mated to treated males. Cigarette decreases levels of this medication. Garlic: May decrease the serum concentration of Protease Inhibitors. Management: Concurrent use of garlic supplements with protease inhibitors is not recommended. generic aceon online europe
Rietsema WJ. Fever, erythroderma, abdominal pain, and renal failure following initiation of indinavir therapy. Clin Inf Dis. Acute hepatitis sometimes resulting in hepatic failure and death reported; causal relationship not established. Continue to take indinavir even if you feel well. Do not miss any doses. Elderly: Use with caution in elderly patients. Treatment of more severe episodes of PCP with MEPRON has not been studied. Therapy with indinavir should be administered cautiously in patients with a current or past history of nephrolithiasis. It is crucial that patients receive adequate hydration. Who should not take ZERIT? In a 1997 postmarketing report, the average time to onset of protease inhibitor PI-related hyperglycemic event was 76 days. However, some cases occurred as early as 4 days after the initiation of therapy. The disorder was serious in 32 out of 83 cases, which included 27 hospitalizations and 5 incidents of diabetic ketoacidosis. Indinavir is usually taken every 8 hours around the clock. Take the medicine at the same time each day. Deflazacort: CYP3A4 Inhibitors Strong may increase serum concentrations of the active metabolites of Deflazacort. Management: Administer one third of the recommended deflazacort dose when used together with a strong or moderate CYP3A4 inhibitor. Race E, Dam E, Obry V et al. Analysis of HIV cross-resistance to protease inhibitors using a rapid single-cycle recombinant virus assay for patients failing on combination therapies. AIDS. Henry K, Kitch D, Dube M, et al. "C-Reactive protein levels over time and cardiovascular risk in HIV-infected individuals suppressed on an indinavir-based regimen: AIDS Clinical Trials Group 5056s. Crixivan therapy. The cumulative frequency of nephrolithiasis is substantially higher in pediatric patients 29% than in adult patients 12. Cilostazol: CYP3A4 Inhibitors Strong may increase the serum concentration of Cilostazol. Management: Consider reducing the cilostazol dose to 50 mg twice daily in adult patients who are also receiving strong inhibitors of CYP3A4. clarithromycin
Check with your doctor if you notice a change in the results of your blood or urine sugar tests. Midazolam is extensively metabolized by CYP3A4. Co-administration with Crixivan with or without ritonavir may cause a large increase in the concentration of this benzodiazepine. No drug interaction study has been performed for the co-administration of Crixivan with benzodiazepines. Based on data from other CYP3A4 inhibitors, plasma concentrations of midazolam are expected to be significantly higher when midazolam is given orally. Therefore Crixivan should not be co-administered with orally administered midazolam see whereas caution should be used with co-administration of Crixivan and parenteral midazolam. Data from concomitant use of parenteral midazolam with other protease inhibitors suggest a possible 3-4 fold increase in midazolam plasma levels. Concomitant use of fluticasone propionate and Crixivan may increase plasma concentrations of fluticasone propionate. Use with caution. Consider alternatives to fluticasone propionate, particularly for long-term use. It is important to continue taking this medication as prescribed even if you feel well. To help you remember, take it at the same times each day. Do not stop taking this medication without consulting your doctor. Corticosteroids Orally Inhaled: CYP3A4 Inhibitors Strong may increase the serum concentration of Corticosteroids Orally Inhaled. Management: Orally inhaled fluticasone propionate with a strong CYP3A4 inhibitor is not recommended. Exceptions: Beclomethasone Oral Inhalation; Triamcinolone Systemic. Not all side effects for indinavir may be reported. You should always consult a doctor or healthcare professional for medical advice. Crixivan, talk to your doctor about possible drug interactions and side effects. If you take any of these medicines together with Crixivan, you may be at increased risk of side effects such as low blood pressure, visual changes, and penile erection lasting more than 4 hours, which have been associated with sildenafil, tadalafil, and vardenafil. If an erection lasts longer than 4 hours, you should seek immediate medical assistance to avoid permanent damage to your penis. Your doctor can explain these symptoms to you. During postmarketing experience, the interstitial nephritis continued in some patients after stopping indinavir. Patients were required to be treatment-naive to be enrolled in this study. Lercanidipine: CYP3A4 Inhibitors Strong may increase the serum concentration of Lercanidipine. CYP3A4 inhibitor. Monitor patients for signs and symptoms of zopiclone toxicity if these agents are combined. Imidafenacin: CYP3A4 Inhibitors Strong may increase the serum concentration of Imidafenacin. vidalta
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Domingo P, Barcelo M "Efavirenz-induced leukocytoclastic vasculitis. When taken at the same time as Crixivan, these foods can interfere with Crixivan being absorbed into your bloodstream and may lessen its effect. L of water a day unless otherwise directed by your doctor. canada daflon cheap
Do not skip pills even if you do not have sex very often. Protect from moisture. 1 Dispense and store in original container; the desiccant should remain in the original bottle. Sildenafil dose should not exceed a maximum of 25 mg in a 48-hour period in patients receiving concomitant CRIXIVAN therapy. Use with increased monitoring for adverse events. buy truvada stock direct
AIDSTRIALS. From AIDS clinical trials information service database. 1996 Apr. CYP3A4 Inducers Moderate: May decrease the serum concentration of CYP3A4 Substrates. Condra JH, Schleif WA, Blahy OM et al. Dynamics of acquired HIV-1 clinical resistance to the protease inhibitor MK-639. J Acquir Immune Defic Syndr Hum Retrovirol. If you miss a dose by more than 2 hours, wait and then take the next dose at the regularly scheduled time. However, if you miss a dose by less than 2 hours, take your missed dose immediately. Then take your next dose at the regularly scheduled time. Do not take more or less than your prescribed dose of Crixivan at any one time. pramipexole
Calcifediol: CYP3A4 Inhibitors Strong may increase the serum concentration of Calcifediol. Monpoux F, Sirvent N, Cottalorda J et al. Stavudine, lamivudine and indinavir in children with advanced HIV-1 infection: preliminary experience. AIDS. Tacrolimus Systemic: Protease Inhibitors may decrease the metabolism of Tacrolimus Systemic.